As of April 5, 2021, there have been a total of 6989 confirmed COVID-19 pediatric cases (<21 years of age) in District of Columbia (DC) residents since the pandemic began. Children infected with SARS-CoV-2 are also at risk for developing MIS-C (multisystem inflammatory syndrome in children). MIS-C is a novel syndrome related to infection with SARS-CoV-2 with manifestations that overlap with Kawasaki disease and toxic shock syndrome. As of April 5, 2021, a total of 26 confirmed cases of MIS-C have been reported to DC Health. Pediatric healthcare provider (PHP) awareness of MIS-C will aid early recognition, diagnosis, and rapid treatment. This health notice provides guidance on reporting and clinical considerations for children infected with SARS-CoV-2.