Several significant new variants of SARS-CoV-2 emerged in the fall of 2020 and are circulating globally, including in the United States. On February 11th 2021, the first cases of variant B.1.17 and B.1.351 were detected in the District of Columbia. The emergence of variants has caused widespread concern in the medical and scientific community as well as among the public. Much remains unknown about the SARS-CoV-2 variants. New information about the virologic, epidemiologic, and clinical characteristics of these variants is rapidly emerging. This Health Notice provides information for healthcare providers on what is currently known about the SARS-CoV-2 variants and provides resources providers can use to access the most up-to-date information.