In December of 2020, the U.S. Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for the Pfizer-BioNTech and Moderna COVID-19 vaccines in the United States. The vaccines have been shown to be safe and effective in large-scale clinical trials involving more than 70,000 individuals. Vaccines are now widely available. Real-world clinical experience with the COVID-19 vaccines continues to confirm their safety and efficacy, and have allowed for fully vaccinated person to resume normal activities. This health notice provides information on safe administration, clinical considerations, reporting requirements, and highlights important resources for healthcare providers.