On March 4, 2020 the Centers of Disease Control and Prevention (CDC) updated its criteria for the evaluation of Persons Under Investigation (PUI), expanding it to include a wider group of symptomatic patients (https://www.cdc.gov/coronavirus/2019-nCoV/hcp/clinical-criteria.html). Consistent with the CDC guidance, only patients who meet specific PUI criteria based on exposure and clinical factors and who are pre-approved by DC Health will be tested through the DC Department of Forensic Sciences Public Health Laboratory (DFS PHL). This Health Notice describes the PUI criteria for testing, which are based on exposure risk and signs or symptoms compatible with illness, and the community risk in the District of Columbia. This Health Notice also includes the processes for testing approvals.