Antimicrobial resistance (AR) is a critical public health threat and patient care and safety issue. The Centers for Disease Control and Prevention (CDC) recently released an updated report, Antibiotic Resistance Threats in the United States, 2019 (2019 AR Threats Report)1 that underscores the continued threat of antimicrobial resistance in the United States (U.S.). More than 2.8 million infections and 35,000 deaths caused by AR bacteria and fungi occur in the U.S. each year. The report categorized 18 pathogens into one of three categories: urgent, serious, and concerning. Of critical importance are extremely drug-resistant Gram-negative bacteria such as Carbapenem-resistant Enterobacteriaceae (CRE), which have spread widely across the U.S. In some cases, these emerging multidrug-resistant organisms (MDROs) have become pan-resistant, essentially making them untreatable. CDC has developed guidelines for the aggressive infection prevention and control efforts necessary to halt the emergence and spread of these new forms of AR pathogens. The purpose of this Health Notice is to increase awareness of the burden of AR and emphasize the additional actions needed to address these threats to prevent further spread in the District of Columbia (DC).