The 2022 global mpox (formerly monkeypox) outbreak is ongoing despite the decline in cases since August 2022. Cases continue to be reported in the United States and around the world. A recent increase in mpox cases in Chicago this spring including people who were fully vaccinated for mpox has highlighted the potential for a possible resurgence in mpox cases as the US enters the summer and people gather for events and celebrations. The purpose of this Health Alert Notice is to provide situational updates and to provide updated recommendations for patient evaluation, testing, and infection control. Healthcare providers should continue to monitor the DC Health Alert Notice webpage for updates at dchealth.dc.gov/page/health-notices.