The Centers for Disease Control and Prevention (CDC) issued a Health Alert Network Health Advisory on December 22, 2022, and a follow up report on March 10, 2023 about an increase in invasive Group A Streptococcus (iGAS) infections. The increase has been most notable in children and adolescents. CDC highlighted the importance of early recognition, diagnosis, and appropriate treatment of these infections in children and adults. As of April 7, 2023, a total of 10 confirmed cases of iGAS have been reported to DC Health including 1 death and 1 case in a child <1 year. This health notice provides guidance on the diagnosis and treatment of GAS infections and reporting requirements in the District of Columbia.